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Ability was randomly developed and the peri-tendinous fibroblasts proliferated not only in the injured area, but also they randomly invaded into the peri-tendinous tissues such as skin, subcutaneous fascia and muscle and proliferated and manufactured a haphazard granulation tissue throughout these structures. Thus, the potential of the healing response of the ICTs was divided into different region
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Ability was randomly developed and the peri-tendinous fibroblasts proliferated not only in the injured area, but also they randomly invaded into the peri-tendinous tissues such as skin, subcutaneous fascia and muscle and proliferated and manufactured a haphazard granulation tissue throughout these structures. Thus, the potential of the healing response of the ICTs was divided into different region
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R clinical stage and proximal location compared to those within the NCCH cohort.DNA and RNA extractionDNA was extracted from a 5 m- or 10 m-thick formalin-fixed paraffin-embedded (FFPE) tissue of each patient with colorectal cancer through the use of QIAmp DNA FFPE tissue kit (Qiagen, Valencia, CA, USA). Total RNA including miRNA fraction was extracted from the FFPE tissue of each colorectal cance
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Ional claims in published maps and institutional affiliations.Quadri et al. BMC Cancer (2017) 17:Page 12 ofAuthor details 1 Thoracic and Gastrointestinal Oncology Branch, Gastrointestinal Oncology Section, Investigator Center for Cancer Research, National Cancer Institute, Building 10 - Hatfield CRC, Room 4-5950, Bethesda, MD 20892, USA. 2 Laboratory of Pathology, National Cancer Institute, Bethes
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Assay. The cell viability assay revealed that miR-193a-3p overexpression significantly inhibited cell viability compared to overexpression of the precursors of a negative control in all three colorectal cancer cell lines analyzed (23?8 ; Fig. 3a). This inhibitoryTakahashi et al. BMC Cancer (2017) 17:Page 6 ofTable 2 Up-regulated and down-regulated miRNAs of BRAFmutant colorectal cancer samples scr
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Gnificantly down-regulated (P = 0.09) in BRAF-mutant cancers compared to KRAS-mutant cancers (Fig. 2). Furthermore, these three miRNAs were shown to be significantly dysregulated in BRAF-mutant cancers compared to normal colonic mucosa (n = 11; Fig. 2), which suggests that the alteration in these miRNA expressions may contribute, at least in part, to the carcinogenesis of BRAF-mutant tumors. Of th
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An colorectal cancer cell lines DiFi, HCT8, LIM2405, and SW48 were kindly provided along with appropriate ethics rules and consents of both institutions by Dr. Mariadason in Ludwig Institute for Cancer Research, Australia. The cell lines were regularly authentificated by short tandem repeat analysis. RKO was cultured in Dulbecco's Modified Eagle's Medium (Sigma-Aldrich, St.Louis, MO, USA) with 10
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S 1. Lefranc F, Facchini V, Kiss R: Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist 2007, 12:1395?403. 2. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E,