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Cludes several genes that are involved in drug metabolism and disposition. Xenobiotic Phase I and II biotransformation enzyme genes induced by BaP include genes encoding a cytochrome P450 family 3 (CYP3-like-2, CBY21750), carboxylesterase, glutathione S-transferase alpha (GSTa), thiosulfate sulfurtransferase and thioredoxin. Genes encoding Phase III transport proteins, ABC transporters and solute
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Ntracellular domain of the AT1 receptors which may also mask the epitopes [177]. An additional post-translational modification is proteolytic cleavage of the receptor into smaller fragments following internalization. Cook et al. [178] demonstrated formation of a 54 amino acid carboxy terminal fragment of the rat AT1a receptor that translocated to the nucleus and induced apoptosis in a variety of c
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Use both affected many extracellular proteins, possibly including yet un-characterized structural proteins ofFourteen genes differentially regulated in tiling arrays were selected for validation using qPCR (Additional file 1, Table S4). The results showed good agreement between the two expression assays (Pearson's correlation coefficient, r = 0.93) (Figure 6). The directions of changes in log tran
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Us cell adherence assays were repeated using S. aureus grown under iron-limited conditions. Consistent with our previous results (Figure 4A), we saw a similar significant reduction in adherence to squames by S. aureus DclfB and by wild-type S. aureus pre-incubated with L2v, with no further reduction in adherence when S. aureus DclfB was pre-incubated with L2v compared to GST alone (Figure S4). The
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E the ability of particulate delivery systems to stimulate stronger immuneE the ability of particulate delivery systems to stimulate stronger immune responses by triggering and cross-linking specific B cell antigen receptors. Within this context, the E2 nanoparticle may be particularly useful as repetitive antigen delivery system due to its potential to display up to 60 copies of an antigen
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15] we propose a model in which SP-A regulates host defense function by both indirect and direct mechanisms. The indirect effects, as documented in this study, comprise a broad-based regulation of levels of expression of a number of BAL proteins important for innate immunity and host defense function. In the K. pneumoniae model employed here these deficits were rapidly reversed by the infectious c
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Accharide (LPS) component of the outer cell membrane. Such a toxicAccharide (LPS) component of the outer cell membrane. Such a toxic component triggers secretion of pro-inflammatory cytokines, and it often requires extensive and expensive removal during protein purification, thus affecting the final yield. It was shown that solubility and stability of recombinant E2 scaffolds that precipitat
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Nvironmental or clinical factors are associated with recovery.and commentaries byNvironmental or clinical factors are associated with recovery.and commentaries by the many impressive consumer spokespersons for the recovery model are informative, but it is difficult to extrapolate from these sources of information. It is clear that the professional and scientific communities have not sufficie